Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever

ALC Otero, LYV Méndez, VV Kouznetsov

Index: Carreno Otero, Aurora L.; Vargas Mendez, Leonor Y.; Duque L., Jonny E.; Kouznetsov, Vladimir V. European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 392 - 400

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Citation Number: 4

Abstract

Abstract Girgensohnine alkaloid was used as a natural model in the design and generation of new alkaloid-like α-aminonitrile series that was completed by the use of SSA-catalyzed Strecker reaction between commercial and inexpensive substituted benzaldehydes, piperidine (pyrrolidine, morpholine and N-methylpiperazine) and acetone cyanohydrin. Calculated ADMETox parameters of the designed analogs revealed their good ...