Novel quinolizidinyl derivatives as antiarrhythmic agents

I Vazzana, R Budriesi, E Terranova, P Ioan…

Index: Vazzana, Iana; Budriesi, Roberta; Terranova, Emanuela; Ioan, Pierfranco; Ugenti, Maria Paola; Tasso, Bruno; Chiarini, Alberto; Sparatore, Fabio Journal of Medicinal Chemistry, 2007 , vol. 50, # 2 p. 334 - 343

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Citation Number: 14

Abstract

Eighteen analogues of lidocaine, mexiletine, and procainamide were synthesized, replacing their aminoalkyl chains with the rigid and cumbersome quinolizidine nucleus. The target compounds were tested for antiarrhythmic, inotropic, and chronotropic effects on isolated guinea pig (gp) heart tissues and to assess calcium antagonist activity. Most compounds exhibited from moderate to high antiarrhythmic activity, and compounds 7, 9, and 19 were ...