Bioorganic & medicinal chemistry

Structure–activity relationships for naturally occurring coumarins as β-secretase inhibitor

S Marumoto, M Miyazawa

Index: Marumoto, Shinsuke; Miyazawa, Mitsuo Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 784 - 788

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Citation Number: 18

Abstract

The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value ...

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