Chemistry Letters

Lanthanoid Triflate Catalyzed Conjugate Addition of Amines to. ALPHA.,. BETA.-Unsaturated Esters. A Facile Route to Optically Active. BETA.-Lactam.

S Matsubara, M Yoshioka, K Utimoto

Index: Matsubara, Seijiro; Yoshioka, Masahito; Utimoto, Kiitiro Chemistry Letters, 1994 , # 5 p. 827 - 830

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Citation Number: 91

Abstract

Catalytic amount of lanthanoid (III) triflates promoted the conjugate addition of amines to 2- alkenoic acid esters to give β-amino esters. The reaction of benzylamine with α, β- unsaturated esters containing a stereogenic center at γ-position proceeded diastereoselectivity to yield optically active β-lactam precursors.

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