Potential carcinostatics V. Synthesis and properties of potential inhibitors of the adenylosuccinate synthetase and adenylosuccinate lyase system

MJ Wanner, EM Van Wijk, GJ Koomen…

Index: Wanner; Van Wijk; Koomen; Pandit Recueil des Travaux Chimiques des Pays Bas, 1980 , vol. 99, # 1 p. 20 - 23

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Citation Number: 9

Abstract

Abstract β, β-Dimethylaspartic acid was obtained by the aluminium-amalgam reduction of the O-methyloxime of diethyl 2-oxo-3, 3-dimethyl-1, 4-butanedioate and subsequent hydrolysis. The (latter) diester was conveniently prepared by the condensation of ethyl 2- bromo-2-methylpropionate with diethyl oxalate, under the influence of magnesium. β, β- Difluoroaspartic acid, threo β-methylaspartic acid and β, β-dimethylaspartic acid (as ...