Tetrahedron

Pallado-catalysed P-arylations and P-vinylation of 2-hydrogeno-2-oxo-1, 4, 2-oxazaphosphinanes

JL Pirat, J Monbrun, D Virieux, HJ Cristau

Index: Pirat, Jean-Luc; Monbrun, Jerome; Virieux, David; Cristau, Henri-Jean Tetrahedron, 2005 , vol. 61, # 29 p. 7029 - 7036

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Citation Number: 27

Abstract

A simple and effective preparation of 2-aryl-(or 2-vinyl)-1, 4, 2-oxazaphosphinanes, phosphorus analogues of aryl-morpholinols has been developed, involving palladium catalysed coupling of aryl (or vinyl)-halides with 2-H-1, 4, 2-oxazaphosphinane in presence of triethylamine. A deprotection step was also proposed to afford the corresponding P-aryl-α- aminobenzylphosphinic acid.

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