Product distribution in the metalation of some aromatic substrates with n-butyllithium

DA Shirley, JR Johnson, JP Hendrix

Index: Shirley,D.A. et al. Journal of Organometallic Chemistry, 1968 , vol. 11, p. 209 - 216

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Citation Number: 68

Abstract

Abstract The following compounds were metalated with n-butyllithium in ether and product isomer ratios determined with the aid of vapor phase chromatographic techniques: anisole, trifluoromethylbenzene, phenetole, m-cresol methyl ether, resorcinol dimethyl ether and biphenyl. The data with all substrates except biphenyl are in accord with the view of relative rate of attack of different ring positions controlled by inductive effects of ring substituent on ...