Synlett

A Modified Bouveault Reaction for the Preparation of α, α-Dimethylamines from Amides

SM Denton, A Wood

Index: Denton, Stephen M.; Wood, Anthony Synlett, 1999 , # 1 p. 55 - 56

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Citation Number: 15

Abstract

Abstract: A modified Bouveault reaction1 for the efficient synthesis of a, a-dimethylamines from the corresponding amides is described. Thus, pretreatment of the amide with zirconium or titanium tetrachloride followed by reaction with an excess of methylmagnesium bromide furnishes the desired a, a-dimethylamines in moderate to good yields. Key words: α, α- dimethylamine, amide, methylmagnesium bromide, zirconium tetrachloride, titanium ...