Tetrahedron

Transmission d'un effet stérique péri à travers un noyau hétéroaromatique—II: Influence sur la réactivité à longue distance

G Maury, C Pigiere

Index: Maury, G.; Pigiere, C. Tetrahedron, 1981 , vol. 37, p. 91 - 95

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Citation Number: 3

Abstract

The quantitative nucleophilic reactivity of alkyl and dialkylimidazo [1, 2-a] pyridines towards methyl iodide is described. In the series of monomethyl derivatives the 7-methyl compound is the most activated and the 8-methyl compound the most deactivated. The effects of two alkyl substituants on the rate of alkylation are additive in the absence of intramolecular steric interaction. On the contrary a deactivation of N1 is observed for the peri disubstituted ...