European journal of medicinal chemistry

First synthesis of novel spin-labeled derivatives of camptothecin as potential antineoplastic agents

YQ Liu, X Tian, L Yang, ZC Zhan

Index: Liu, Ying-Qian; Tian, Xuan; Yang, Liu; Zhan, Zong-Cheng European Journal of Medicinal Chemistry, 2008 , vol. 43, # 11 p. 2610 - 2614

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Citation Number: 16

Abstract

In an effort to improve the stability of labile lactone ring and water solubility of camptothecin, five novel spin-labeled camptothecin derivatives were synthesized in quantitative yield by a simple modification of the carbodiimide method using the combination of scandium triflate (Sc (OTf) 3) and 4-dimethylaminopyridine (DMAP), and the in vitro pharmacokinetic determination of the lactones of representative compound 13a showed that the biological ...