Antileukemic activity of ungeremine and related compounds. Preparation of analogs of ungeremine by a practical photochemical reaction
RKY Zee-Cheng, SJ Yan…
Index: Zee-Cheng,K.-Y. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 199 - 203
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Citation Number: 69
Abstract
2-Methyl-3-nitropyridine-6-carboxamide (54). To a solution of NHzOH in 90% EtOH (40 mL), prepared from NHzOH-HC1 (0.6 g, 8.5 mmol) and NaOAc (0.7 g, 8.5 mmol), was added portionwise a solution of the aldehyde 5612 (1.8 g, 10 mmol). The mixture was stirred at 80" C for 30 min and cooled to give a crystalline product 57 (1.3 g, 66.4%), mp 217-219" C. Anal.(C7H7N303) C, H, N.
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