Facile synthesis of 2', 5'-dideoxy-5-fluorouridine by thymidine phosphorylase

…, NS Cauchon, JF Kozlowski, CJ Chang

Index: Chae; Cauchon; Kozlowski; Chang Journal of Organic Chemistry, 1992 , vol. 57, # 3 p. 1002 - 1005

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Citation Number: 6

Abstract

The antitumor agent 5-fluorouracil (BFUra, 1) was first synthesized by Heidelberger et al. in 1957.'Many attempts have been made since then to prepare derivatives of 5-FUra in the search for compounds with greater selectivity against tumor tissuea. 2-4 One of theae compounds,