2, 4, 6-Trichlorophenylhydrazine Schiff bases as DPPH radical and super oxide anion scavengers

…, V Uddin Ahmad, M Khan, M Taha, F Rahim…

Index: Khan, Khalid Mohammed; Shah, Zarbad; Ahmad, Viqar Uddin; Khan, Momin; Taha, Muhammad; Rahim, Fazal; Ali, Sajjad; Ambreen, Nida; Perveen, Shahnaz; Choudhary, M. Iqbal; Voelter, Wolfgang Medicinal Chemistry, 2012 , vol. 8, # 3 p. 452 - 461

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Citation Number: 21

Abstract

Syntheses of thirty 2, 4, 6-trichlorophenylhydrazine Schiff bases 1-30 were carried out and evaluated for their in vitro DPPH radical and super oxide anion scavenging activities. Compounds 1-30 have shown a varying degree of DPPH radical scavenging activity and their IC50 values range between 4.05-369.30 μM. The compounds 17, 28, 18, 14, 8, 15, 12, 2, 29, and 7 exhibited IC50 values ranging between 4.05±0.06-24.42±0.86 μM which are ...