Synthesis

Acid-and base-stable esters: A new protecting group for carboxylic acids

M Kurosu, K Biswas, P Narayanasamy, DC Crick

Index: Kurosu, Michio; Biswas, Kallolmay; Narayanasamy, Prabagaran; Crick, Dean C. Synthesis, 2007 , # 16 p. 2513 - 2516

Full Text: HTML

Citation Number: 2

Abstract

Abstract An acid-and base-stable protecting group for carboxylic acids is described. The esters of (2, 6-dichloro-4-methoxyphenyl)(2, 4-dichlorophenyl) methanol are stable to Brønsted and Lewis acids, Brønsted bases, and a wide variety of nucleophiles; however, the esters can be conveniently deprotected by a solvolytic displacement reaction with 20% trifluoroacetic acid.

Related Articles:

Synthesis and Biological Properties of Enkephalin??like Peptides Containing Carboranylalanine in Place of Phenylalanine

[Schwyzer; Do; Eberle; Fauchere Helvetica Chimica Acta, 1981 , vol. 64, # 7 p. 2078 - 2083]

Synthesis of chiral α-amino acids

[Chakraborty, Tushar K.; Ghosh, Animesh Tetrahedron Letters, 2002 , vol. 43, # 52 p. 9691 - 9693]

Optically active helical substituted polyacetylenes as chiral seeding for inducing enantioselective crystallization of racemic n-(tert-butoxycarbonyl) alanine

[Chen, Bo; Deng, Jianping; Cui, Xin; Yang, Wantai Macromolecules, 2011 , vol. 44, # 18 p. 7109 - 7114]

Papain-Assisted Resolution of Natural and Xenobiotic α-Amino Acid

[Moriniere, J. L.; Danree, B.; Lemoine, J.; Guy, A. Synthetic Communications, 1988 , vol. 18, # 4 p. 441 - 444]

Synthesis of chiral α-amino acids

[Chakraborty, Tushar K.; Ghosh, Animesh Tetrahedron Letters, 2002 , vol. 43, # 52 p. 9691 - 9693]

More Articles...