Synthesis and Biological Evaluation of 1??Phenyl??1, 2, 3, 4??dihydroisoquinoline Compounds as Tubulin Polymerization Inhibitors

CH Zheng, J Chen, J Liu, XT Zhou, N Liu…

Index: Zheng, Can-Hui; Chen, Jun; Liu, Jia; Zhou, Xiao-Tian; Liu, Na; Shi, Duo; Huang, Jing-Jing; Lv, Jia-Guo; Zhu, Ju; Zhou, You-Jun Archiv der Pharmazie, 2012 , vol. 345, # 6 p. 454 - 462

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Citation Number: 11

Abstract

Abstract A series of 1-phenyl-3, 4-dihydroisoquinoline derivatives and several 1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline, 1-phenyl-isoquinoline analogues were synthesized, and their cytotoxicity and tubulin polymerization inhibitory activity were evaluated. The 1-phenyl-3, 4- dihydroisoquinoline compounds were found to be potential tubulin polymerization inhibitors. Compound 5n, bearing a 3′[BOND] OH and 4′[BOND] OCH 3 substituted 1-phenyl B- ...