Development of a diastereoselective phosphorylation of a complex nucleoside via dynamic kinetic resolution

K Tran, GL Beutner, M Schmidt, J Janey…

Index: Cremlyn,R.J.W. et al. Journal of the Chemical Society [Section] C: Organic, 1971 , p. 2028 - 2031

Full Text: HTML

Citation Number: 4

Abstract

... The Journal of Organic Chemistry. ... A stable phosphoramidic acid derivative is coupled to the nucleoside, in a process mediated by HATU and quinine, to deliver the coupled product in high chemical yield and good diastereoselectivity. ...

Related Articles:

Studies of organophosphorochloridates. Part I. Synthesis of N-substituted phosphoramidic chlorides and acids

[Cremlyn,R.J.W. et al. Journal of the Chemical Society [Section] C: Organic, 1971 , p. 300 - 303]

Asymmetric ylide reactions: epoxidation, cyclopropanation, aziridination, olefination, and rearrangement

[Michaelis; v. Soden Justus Liebigs Annalen der Chemie, 1885 , vol. 229, p. 339]

More Articles...