Synthesis and biological evaluation of compounds which contain pyrazole, thiazole and naphthalene ring as antitumor agents

…, PF Wang, X Zhang, YA Yang, Y Yin, F Zhang…

Index: Yuan, Ji-Wen; Wang, She-Feng; Luo, Zhong-Liang; Qiu, Han-Yue; Wang, Peng-Fei; Zhang, Xin; Yang, Yong-An; Yin, Yong; Zhang, Fei; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2324 - 2328

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Citation Number: 14

Abstract

Abstract A series of compounds which contain pyrazole, thiazole and naphthalene ring (1a– 7a, 1b–7b, 1c–7c, 1d–7d) were firstly synthesized and their anti-proliferative activity, EGFR inhibitory activity, cytotoxicity and inhibition to Hela cell migration were evaluated. Compound 2-(3-(3, 4-dimethylphenyl)-5-(naphthalen-2-yl)-4, 5-dihydro-1H-pyrazol-1-yl) thiazol-4 (5H)-one (7d) displayed the most potent inhibitory activity (IC 50= 0.86 μM for ...