Studies on the kinetics of racemization of 2, 4-disubstituted-5 (4 H)-oxazolones

M Slebioda, MA St-Amand, FMF Chen…

Index: Slebioda, Marek; St-Amand, Marc A.; Chen, Francis M. F.; Benoiton, N. Leo Canadian Journal of Chemistry, 1988 , vol. 66, p. 2540 - 2544

Full Text: HTML

Citation Number: 16

Abstract

The kinetics of racemization of 2, 4-disubstituted-5 (4 H)-oxazolones obtained from N-acetyl, N-benzoyl, and N-benzyloxycarbonylglycyl-l-leucine,-valine, and-phenylalanine have been studied in several solvents alone and in the presence of tertiary amines. The influence of the nature of the substituents on the rate of the reaction has been evaluated, and the values of the activation parameters Δ H≠ and Δ S≠ for the base-catalyzed reactions have been ...