Synthesis of Antimalarials. VIII. 1 1-(7-Chloro-2-phenylquinolyl-4)-6-diethylaminohexanedione-1, 3 and Certain Other Compounds

JC Shivers, CR Hauser

Index: Shivers; Hauser Journal of the American Chemical Society, 1948 , vol. 70, p. 437

Full Text: HTML

Citation Number: 6

Abstract

Anal. Calcd. for ClcH1404Na: C, 67.07; H, 4.38; N, 8.70. Found: C, 67.39; H, 4.50; N, 8.86. 1- (7'-Chloro-2'-phenylquinoline4')-5-diethylaminohexanedione-1, 3 (11) was prepared by acylating 1-diethylaminopentanone-4 (V) with ethyl 2-phenyl-7-chlorocinchoninate (VI) by means of sodium amide according to an adaptation of the method developed in this Laboratory. ll To a stirred suspension of 0.4 mole of sodium amide" in 500 ml. of liquid ...

Related Articles:

Microwave-irradiated synthesis and antimicrobial activity of 2-phenyl-7-substitutedalkyl/arylaminoquinoline-4-carboxylic acid derivatives

[Bhatt, Hardik G.; Agrawal, Yadvendra K. Medicinal Chemistry Research, 2010 , vol. 19, # 4 p. 392 - 402]

The Synthesis of Potential Antimalarials. 2-Phenyl-α-(2-piperidyl)-4-quinolinemethanols1, 2

[Rapport et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 2697,2700]

More Articles...