Enzymatic acylation using acid anhydrides: crucial removal of acid

…, CG Rabiller, K Königsberger, K Faber, H Griengl

Index: Berger, B.; Rabiller, C. G.; Koenigsberger, K.; Faber, K.; Griengl, H. Tetrahedron: Asymmetry, 1990 , vol. 1, # 8 p. 541 - 546

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Citation Number: 94

Abstract

Abstract An efficient enzymatic resolution of 7, 7-disubstituted 1, 4, 5, 6-tetrachlorobicyclo [2.2. 1] hept-5-en-2-ols was accomplished by means of lipase AY-30 from Candida cylindracea in toluene. When acid anhydrides were used as acyl donors, the enantioselectivity was found to depend strongly on the reaction conditions: Whereas low selectivity (E< 20) was observed without precautions taken in order to remove the co- ...