Design, synthesis, and structure–activity relationship of novel CCR2 antagonists

S Kothandaraman, KL Donnely, G Butora, R Jiao…

Index: Kothandaraman, Shankaran; Donnely, Karla L.; Butora, Gabor; Jiao, Richard; Pasternak, Alexander; Morriello, Gregori J.; Goble, Stephen D.; Zhou, Changyou; Mills, Sander G.; MacCoss, Malcolm; Vicario, Pasquale P.; Ayala, Julia M.; DeMartino, Julie A.; Struthers, Mary; Cascieri, Margaret A.; Yang, Lihu Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1830 - 1834

Full Text: HTML

Citation Number: 21

Abstract

A series of novel 1-aminocyclopentyl-3-carboxyamides incorporating substituted tetrahydropyran moieties have been synthesized and subsequently evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog 59 was found ...