Synthesis, cell-growth inhibition, and antitumor screening of 2-(pn-butylanilino) purines and their nucleoside analogs

GE Wright, L Dudycz, Z Kazimierczuk…

Index: Wright, George E.; Dudycz, Lech W.; Kazimierczuk, Zygmunt; Brown, Neal C.; Khan, Naseema N. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 109 - 116

Full Text: HTML

Citation Number: 33

Abstract

Derivatives of N2-(pn-butylpheny1) guanine (BuPG) and 2-(pn-butylanilino) adenine (BuAA) were synthesized and tested as inhibitors of mammalian DNA polymerase a, cell growth, and macromolecule synthesis. 2-(pn-Butylanilino)-6-chloropurine (BuAC1) served as a useful intermediate to prepare a series of 6-substituted analogues. BuACI, as its sodium salt, reacted with 2-deoxy-3, 5-di-p-toluoyl-~-~-ribofuranosyl chloride in acetonitrile to give 64 ...