Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands

…, JY Kim, ME Jung, K Ahn, SU Kim, J Kim, J Lee

Index: Song, Kwang-Seop; Lee, Sung-Han; Chun, Hyun Ji; Kim, Jong Yup; Jung, Myung Eun; Ahn, Kwangwoo; Kim, Soo-Un; Kim, Jeongmin; Lee, Jinhwa Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 4035 - 4051

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Citation Number: 19

Abstract

After the CB1 receptor antagonist SR141716 (rimonabant) was previously reported to modulate food intake, CB1 antagonism has been considered as a new therapeutic target for the treatment of obesity. Several series of urea, carbamate, amide, sulfonamide and oxalamide derivatives based on 1-benzhydrylpiperazine scaffold were synthesized and tested for CB1 receptor binding affinity. The SAR studies to optimize the CB1 binding ...

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