Elimination of Chlorine (Radical) or Tosylate (Anion) from C2'of Nucleoside C3'Free Radicals as Model Reactions Postulated To Occur at the Active Site of …

MJ Robins, Z Guo, SF Wnuk

Index: Robins; Guo; Wnuk Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3637 - 3638

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Citation Number: 25

Abstract

Ribonucleotide reductases (RNRs) catalyze the conversion of ribonucleoside 5′-di-or- triphosphates to 2′-deoxynucleotides that are required for DNA biosynthesis. 2 The ribonucleoside diphosphate reductase (RDPR) from Escherichia coli (EC 1.17. 4.1) has two nonidentical subunits (R1 and R2) whose structures have been determined by X-ray crystallography. 3 The R1 subunit contains allosteric control sites and five cysteine ...

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