Tetrahedron letters

Conversion of carbonimidodithioates into unsymmetrical Di-and Tri-substituted ureas including urea dipeptides

M Anbazhagan, ARAS Deshmukh, S Rajappa

Index: Anbazhagan, Mariappan; Deshmukh, Abdul Rakeeb A. S.; Rajappa, Srinivasachari Tetrahedron Letters, 1998 , vol. 39, # 21 p. 3609 - 3612

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Citation Number: 14

Abstract

Selective hydrolysis of carbonimidodithioates (3) leads to the thiocarbamates (4), which can be easily transformed to the unsymmetrical ureas (5) by treatment with the appropriate amines. This constitutes a synthesis of ureas without the use of phosgene or carbon monoxide.

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