Design, synthesis and antidiabetic evaluation of oxazolone derivatives

G Mariappan, BP Saha, S Datta, D Kumar…

Index: Mariappan; Saha; Datta, Sriparna; Kumar, Deepak; Haldar Journal of Chemical Sciences, 2011 , vol. 123, # 3 p. 335 - 341

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Citation Number: 21

Abstract

Abstract A series of ten novel (2a–j) 4-arylidine 2-[4-methoxy phenyl] oxazol-5-one derivatives were synthesized and assayed in vivo to investigate their antidiabetic activities by streptozotocin-induced model in rat. These derivatives showed considerable biological efficacy when compared to rosiglitazone, a potent and well-known antidiabetic agent as a reference drug. All the compounds were effective, amongst them 2d shows more ...