Synthesis and Pharmacological Investigations of Some 4??Hydroxycoumarin Derivatives

I Manolov, ND Danchev

Index: Manolov, Ilia; Danchev, Nicolay D. Archiv der Pharmazie, 2003 , vol. 336, # 2 p. 83 - 94

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Citation Number: 29

Abstract

Abstract The synthesis of ten coumarin derivatives of 4-hydroxycoumarin and various unsaturated ketones and aldehydes is described. The structures of the synthesized compounds were confirmed by IR, 1 H-NMR, and mass-spectral data. Acute toxicity studies of the compounds were performed on mice by oral and intraperitoneal administration. A comparative pharmacological study of the in vivo anticoagulant effects of the derivatives ...