Tetrahedron letters

Synthesis of heterocycles via ligand-free palladium catalyzed reductive Heck cyclization

P Liu, L Huang, Y Lu, M Dilmeghani, J Baum, T Xiang…

Index: Liu, Pingli; Huang, Liang; Lu, Yuelie; Dilmeghani, Mina; Baum, Jean; Xiang, Tingjian; Adams, Jeff; Tasker, Andrew; Larsen, Rob; Faul, Margaret M. Tetrahedron Letters, 2007 , vol. 48, # 13 p. 2307 - 2310

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Citation Number: 31

Abstract

Synthesis of five and six membered heterocycles, indolines, 2, 3-dihydrobenzofurans, chromans, isochromans, 1, 2, 3, 4-tetrahydroquinolines, and 1, 2, 3, 4- tetrahydroisoquinolines, in 70–99% yield by a ligand-free palladium catalyzed reductive Heck cyclization of phenyl bromides and chlorides, under mild conditions, is reported. Water was found to be essential for these reactions.

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