A new model of binding of rifampicin and its amino analogues as zwitterions to bacterial RNA polymerase

K Pyta, P Przybylski, K Klich, J Stefańska

Index: Pyta, Krystian; Przybylski, Piotr; Klich, Katarzyna; Stefanska, Joanna Organic and Biomolecular Chemistry, 2012 , vol. 10, # 41 p. 8283 - 8297,15

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Citation Number: 10

Abstract

Seven new benzyl (3–9) and four new phenethyl (10–13) amino analogues of ansa- macrolide rifampicin (1) were synthesized using the optimised method of reductive amination. Structures of 3–13 in solution were determined by 1D and 2D NMR and FT-IR methods whereas the energetically most favoured conformation of amino analogues was calculated with the use of the PM5 method. Spectroscopic and semi-empirical studies ...