Journal of Heterocyclic Chemistry

Efficient preparation of 3??substituted quinazolinediones directly from anthranilic acids and isocyanates

N Koay, LC Campeau

Index: Koay, Natalie; Campeau, Louis-Charles Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 2 p. 473 - 478

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Citation Number: 3

Abstract

Abstract An efficient and practical synthesis of 3-substituted quinazolinediones is described. The protocol uses readily available isocyanates and anthranilic acids as precursors in a one- pot operation and has been demonstrated on> 50 g scale. Isolation of the products via filtration directly from the reaction media is facile, affording high-purity material. This procedure was then applied to the synthesis of Zenarestat. J. Heterocyclic Chem.,(2011).

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