Tetrahedron Letters

A novel deacylation during the amination of trifluoromethyl β-dicarbonyl compounds

S Fioravanti, L Pellacani, F Ramadori, PA Tardella

Index: Fioravanti, Stefania; Pellacani, Lucio; Ramadori, Federico; Tardella, Paolo A. Tetrahedron Letters, 2007 , vol. 48, # 44 p. 7821 - 7824

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Citation Number: 14

Abstract

Starting from trifluoromethyl β-dicarbonyl compounds, a rare loss of CF3CO was observed in the amination reactions performed under heterogeneous conditions using NsONHCO2Et as the aminating agent and CaO or NaH as the base, while corresponding nonfluorinated β- dicarbonyl compounds under analogous conditions give non deacylated aminated compounds. This reaction can facilitate a direct synthesis of N-substituted α-amino esters ...

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