New and simple synthesis of acid azides, ureas and carbamates from carboxylic acids: application of peptide coupling agents EDC and HBTU

VV Sureshbabu, HS Lalithamba, N Narendra…

Index: Sureshbabu, Vommina V.; Lalithamba; Narendra; Hemantha Organic and Biomolecular Chemistry, 2010 , vol. 8, # 4 p. 835 - 840

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Citation Number: 17

Abstract

Conversion of carboxylic acids into acid azides using peptide coupling agents, EDC and HBTU is described. The procedure is efficient, practical and applicable to a diverse range of carboxylic acids including N-protected amino acids. Using the same reagents, one-pot synthesis of ureas, dipeptidyl urea esters and carbamates from acids has also been achieved.

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