Design and synthesis of tricyclic derivatives as high density lipoprotein cholesterol enhancers

H Elokdah, SY Chai, D Ho, T Sulkowski

Index: Elokdah, Hassan; Chai, Sie-Yearl; Ho, Douglas; Sulkowski, Theodore Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 3 p. 339 - 342

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Citation Number: 4

Abstract

A pharmacophore for increasing HDLC was proposed based on common structural features of non-thio-containing compounds with HDLC enhancing properties. A search of the compound database identified various series of these non-thio-containing compounds, including a novel tricyclic imidazoisoquinolone. Preparation of l-aryl-3-oxo-1, 3-dihydro-2- benzofuran-1-carboxamides using a novel and widely applicable one-step process from 2 ...