Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics

JJ Chruma, L Liu, W Zhou, R Breslow

Index: Chruma, Jason J.; Liu, Lei; Zhou, Wenjun; Breslow, Ronald Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 20 p. 5873 - 5883

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Citation Number: 26

Abstract

The first functional catalytic mimic of the enzyme dialkylglycine decarboxylase is described. This system utilizes a hydrophobically modified polyethylenimine polymer, a pyridoxamine cofactor, and a 2-aryl-2-alkylglycine sacrificial amine source to convert α-keto acids to α- amino acids at biologically relevant temperatures with multiple turnovers of the pyridoxamine catalyst. The effects of hydrophobic and electronic factors in the 2, 2- ...