Structure and activity studies of glycine receptor ligands. Part 8. Arylidene-imidazoline-4-one aminoacids

J Karolak-Wojciechowska, A Mrozek…

Index: Karolak-Wojciechowska, Janina; Mrozek, Agnieszka; Kiec-Kononowicz, Katarzyna; Handzlik, Jadwiga Journal of Molecular Structure, 2003 , vol. 649, # 1-2 p. 25 - 36

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Citation Number: 8

Abstract

Based on chemical and preliminary biological experiments (inhibition to glycine receptor), structure and activity relationship of arylidene-imidazoline-4-one amino acids has been studied. In the course of our work, the simulation of the hydrogen bonds formation between ligand molecule and hypothetical receptor has been designed. Computed interactions are going to simulate possible ligand–receptor interaction with selected amino acids (in this ...