Esters, amides and substituted derivatives of cinnamic acid: synthesis, antimicrobial activity and QSAR investigations
…, D Belsare, D Pharande, V Mourya, A Dhake
Index: Narasimhan, Balasubramanian; Belsare, Deepak; Pharande, Devayani; Mourya, Vishnukant; Dhake, Avinash European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 827 - 834
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Citation Number: 153
Abstract
A series of esters (Ia–k), substituted derivatives (IIa–d) and amides (IIIa–q) of cinnamic acid were synthesized and evaluated as antibacterial and antifungal agents. All the derivatives belonging to the series I, II and III showed antimicrobial activity comparable to the standard. Compounds If and IIc proved to be the most effective compounds. Quantitative structure– activity relationship (QSAR) investigation with multiple linear regression analysis was ...
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