The Journal of Organic Chemistry

Intermolecular decomposition of N-acylcyanamides

CH Kwon, HT Nagasawa

Index: Kwon, Chul-Hoon; Nagasawa, Herbert T. Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3403 - 3406

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Citation Number: 5

Abstract

(1): Method I. A mixture of 9-0-(tert-butyldimethylsilyl) su-pinidine (7B)(0.75 g, 2.96 mmol) and ammonium fluoride (0.22 g, 5.92 mmol) in dry methanol (60 mL) was stirred and kept at 60'C for 18 h. The solvent was removed under reduced pressure to give a pale-yellow residual oil that was purified by preparative TLC on 2-mm silica gel plates (three times), developing with a mixture of chloroform/methanol/concentrated ammonium hydroxide (10/ ...