Synthesis and anticonvulsant activity of benzimidazo [1, 2-c] quinazolines

LN Vostrova, TA Voronina, TL Karaseva…

Index: Vostrova, L. N.; Voronina, T. A.; Karaseva, T. L.; Gernega, S. A.; Ivanov, E. I.; et al. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 6 p. 404 - 406 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 6 p. 690 - 693

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Citation Number: 18

Abstract

These compounds (I) are usually obtained by acylating 2-o-aminophenylbenzimidazole (II) with carbonyl chlorides, followed by cyclization of the resulting benzimidazole amides (III). We have previously shown [2] that (I) can be obtained in high yields by the direct reaction of (II) with benzoyl chlorides or benzoic anhydrides mixed with acetic acid and acetic anhydride: