Novel synthetic LPDs consisting of different cholesterol derivatives for gene transfer into hepatocytes

J Lu, D Zhu, ZR Zhang, L Hai, Y Wu…

Index: Lu, Jiao; Zhu, Di; Zhang, Zhi-Rong; Hai, Li; Wu, Yong; Sun, Xun Journal of Drug Targeting, 2010 , vol. 18, # 7 p. 520 - 535

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Citation Number: 5

Abstract

In the present study, LPDs composing of a series of novel synthetic cholesterylated derivatives bearing a cluster of galactose residues and different spacer lengths were prepared for performing target gene delivery to hepatocytes and their physiochemical properties as well as gene transfer efficiency were investigated. In agreement with the “clustering effect” known to occur with more complex oligomeric structures, the addition of ...