Organic letters

Cu (II) Catalyzed Imine C–H Functionalization Leading to Synthesis of 2, 5-Substituted 1, 3, 4-Oxadiazoles‡

S Guin, T Ghosh, SK Rout, A Banerjee, BK Patel

Index: Guin, Srimanta; Ghosh, Tuhin; Rout, Saroj Kumar; Banerjee, Arghya; Patel, Bhisma K. Organic Letters, 2011 , vol. 13, # 22 p. 5976 - 5979

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Citation Number: 61

Abstract

A direct access to symmetrical and unsymmetrical 2, 5-disubstituted [1, 3, 4]-oxadiazoles has been accomplished through an imine C–H functionalization of N-arylidenearoylhydrazide using a catalytic quantity of Cu (OTf) 2. This is the first example of amidic oxygen functioning as a nucleophile in a Cu-catalyzed oxidative coupling of an imine C–H bond. These reactions can be performed in air atmosphere and moisture making it exceptionally ...

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