Design and Synthesis of Novel Dual??Action Compounds Targeting the Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection

…, CW Yang, CI Lin, NK Huang, YL Lin, Y Chern…

Index: Chen, Jhih-Bin; Liu, Eric Minwei; Chern, Ting-Rong; Yang, Chieh-Wen; Lin, Chia-I; Huang, Nai-Kuei; Lin, Yun-Lian; Chern, Yijuang; Lin, Jung-Hsin; Fang, Jim-Min ChemMedChem, 2011 , vol. 6, # 8 p. 1390 - 1400

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Citation Number: 11

Abstract

Abstract A novel compound, N 6-(4-hydroxybenzyl) adenosine, isolated from Gastrodia elata and which has been shown to be a potential therapeutic agent for preventing and treating neurodegenerative disease, was found to target both the adenosine A 2A receptor (A 2A R) and the equilibrative nucleoside transporter 1 (ENT1). As A 2A R and ENT1 are proximal in the synaptic crevice of striatum, where the mutant huntingtin aggregate is located, the dual ...