Steroids

Improved synthesis of 3α, 7α, 12α, 24ξ-tetrahydroxy-5 β-cholestan-26-oic acid

AK Batta, GS Tint, B Dayal, S Shefer, G Salen

Index: Batta, A. K.; Tint, G. S.; Dayal, B.; Shefer, S.; Salen, G. Steroids, 1982 , vol. 39, # 6 p. 693 - 702

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Citation Number: 8

Abstract

Abstract This paper describes three simple and short methods for the conversion of cholic acid into cholylaldehyde with protected hydroxyl groups. The first method involves lithium aluminum hydride reduction of the tetrahydropyranyl ether of methyl cholate and oxidation of the resulting primary alcohol with pyridinium chlorochromate. The second method employs diborane for the reduction of the-COOH group to the-CH 2 OH group, while the third ...