Selective derivatization and sequestration of ribose from a prebiotic mix

G Springsteen, GF Joyce

Index: Springsteen, Greg; Joyce, Gerald F. Journal of the American Chemical Society, 2004 , vol. 126, # 31 p. 9578 - 9583

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Citation Number: 80

Abstract

Observations regarding the catalytic potential of RNA and the role of RNA in biology have formed the basis for the “RNA world” hypothesis, which suggests that a genetic system based on self-replicating polyribonucleotides preceded modern biology. However, attempts to devise a realistic prebiotic synthesis of nucleic acids from simple starting materials have been plagued by problems of poor chemical selectivity, lack of stereo-and regiospecificity, ...