Total Syntheses and Biological Evaluation of 3??O??Methylfunicone and Its Derivatives Prepared by TMPZnCl· LiCl??Mediated Halogenation and Carbonylative Stille …

M Ehrlich, T Carell

Index: Ehrlich, Michael; Carell, Thomas European Journal of Organic Chemistry, 2013 , # 1 p. 77 - 83

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Citation Number: 8

Abstract

Abstract The total syntheses of the natural product 3-O-methylfunicone (1), a member of the funicone class of compounds, and its derivatives is reported. The key reactions in the construction of the biaryl ketone core are a regioselective TMPZnCl· LiCl halogenation and a carbonylative Stille cross-coupling reaction. In addition, the inhibitory activities of the funicones against Y-family DNA polymerase κ (pol κ) and polymerase η (pol η) were ...