Synthesis of guanidine derivatives and molecular recognition

Y Qi, H Gao, M Yang, CG Xia, J Suo

Index: Qi, Yanxing; Gao, Haixiang; Yang, Min; Xia, Chun-Gu; Suo, Jishuan Synthetic Communications, 2003 , vol. 33, # 7 p. 1073 - 1079

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Citation Number: 5

Abstract

Abstract Five Guanidine Derivatives bearing acyl group were synthesized by the reaction of acyl chloride with 1, 1, 3, 3-tetramethylguanidine. Their structures were confirmed by IR, 1H- NMR, EI-MS, HRMS and elementary analysis. One of them (4a) was also characterized by X- ray. Preliminary results of interaction with phosphate-containing biomolecules and adipate showed that all of them exhibited the abilities of molecular recognition.