Automated parallel synthesis of chalcone-based screening libraries
DG Powers, DS Casebier, D Fokas, WJ Ryan, JR Troth…
Index: Powers, David G.; Casebier, David S.; Fokas, Demosthenes; Ryan, William J.; Troth, Jonah R.; Coffen, David L. Tetrahedron, 1998 , vol. 54, # 16 p. 4085 - 4096
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Citation Number: 181
Abstract
Using a variety of condensation and cyclization reactions, nine combinatorial arrays of individual chalcone derivatives, over 74,000 in all, were produced in 50 μM quantities. The ease with which a broad range of diversity can be fabricated around a single molecular motif using automated parallel solution phase synthesis has been demonstrated.
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