Aminophosphonic and aminophosphinic acid analogues of aspartic acid

MM Campbell, NI Carruthers, SJ Mickel

Index: Campbell, Malcolm M.; Carruthers, Nicholas I.; Mickel, Stuart J. Tetrahedron, 1982 , vol. 38, # 16 p. 2513 - 2524

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Citation Number: 47

Abstract

4-Oxoazetidin-2-ylphosphonates and phosphinates, obtained from Arbusov reactions of 4- acetoxyazetidin-2-one and 4α-acetoxy-3β-phthalimido-2-one with a variety of phosphites and phosphonites, were hyrdolysed to β-phosphono-and β-phosphino β-alanine (phosphono-and phosphinoaspartic acid) derivatives. In model studies for their incorporation in peptides, conditions for the selective removal of protecting groups for ...