Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors

PM O'Brien, DF Ortwine, AG Pavlovsky…

Index: O'Brien, Patrick M.; Ortwine, Daniel F.; Pavlovsky, Alexander G.; Picard, Joseph A.; Sliskovic, Drago R.; Roth, Bruce D.; Dyer, Richard D.; Johnson, Linda L.; Man, Chiu Fai; Hallak, Hussein Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 156 - 166

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Citation Number: 106

Abstract

A series of biphenylsulfonamide derivatives of (S)-2-(biphenyl-4-sulfonylamino)-3- methylbutyric acid (5) were prepared and evaluated for their ability to inhibit matrix metalloproteinases (MMPs). For this series of compounds, our objective was to systematically replace substituents appended to the biphenyl and α-position of 5 with structurally diverse functionalities to assess the effects these changes have on biological ...