Resolution, absolute stereochemistry, and enantioselective activity of nomifensine and hexahydro-1H-indeno [1, 2-b] pyridines

R Kunstmann, H Gerhards, H Kruse…

Index: Kunstmann, Rudolf; Gerhards, Hermann; Kruse, Hansjoerg; Leven, Margret; Paulus, Erich F.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 798 - 804

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Citation Number: 19

Abstract

Nomifensine and three selected compounds from the series of H4a, HS-truns, H4,, H9~-cis- 2, 3, 4, 4a, 5, 9b-hexahydro-lH-indeno [1,241 pyridines have been resolved into their enantiomers. All compounds exhibit pronounced enantioselective activity with respect to their inhibition of tetrabenazine-induced ptosis and potentiation of yohimbine toxicity. Nomifensine exhibits the same preference for one enantiomer with respect to dopamine ...