Synthesis of potential neuroleptics and tranquillizers: 2-(tert. Amino)-9-(3-dimethylaminopropylidene) thioxanthenes

V Kmoníček, E Svátek, J Holubek…

Index: Kmonicek, Vojtech; Svatek, Emil; Holubek, Jiri; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 4 p. 937 - 947

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Citation Number: 2

Abstract

Abstract 4-Dimethylamino-, 4-pyrrolidino-, 4-piperidino-, 4-morpholino-and 4-(4- methylpiperazino)-thiophenol (IIIa-IIIe), which were prepared by two methods and characterized as the 2, 4-dinitrodiphenyl sulfides IVb-IVe, were transformed by treatment with 2-iodobenzoic acid and copper in aqueous potassium hydroxide to 2-(4-tert. aminophenylthio) benzoic acids (Va-Ve). Cyclization with polyphosphoric acid gave ...